GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1577917 | 1 | rs6933377 | chr6:86705255 | SNHG5 | chr6:86386726-86388451:- | 0.38 | 8.76 | 3.46E-17 | Response to antipsychotic treatment |
| THCA | cis | rs943466 | 1 | rs6933568 | chr6:33751261 | LEMD2 | chr6:33738991-33756906:- | 0.25 | 4.99 | 8.42E-7 | Body mass index |
| THCA | cis | rs943466 | 1 | rs6933607 | chr6:33743997 | LEMD2 | chr6:33738991-33756906:- | 0.25 | 5.01 | 7.83E-7 | Body mass index |
| THCA | cis | rs7769051 | 1 | rs6934161 | chr6:133124077 | C6orf192 | chr6:133090507-133119747:- | 0.23 | 3.86 | 0.000128 | Type 2 diabetes nephropathy |
| THCA | cis | rs9465871 | 1 | rs6935599 | chr6:20717095 | SOX4 | chr6:21593972-21598847:+ | -0.13 | -3.95 | 8.86E-5 | Type 2 diabetes |
| THCA | cis | rs9380516 | 1 | rs6935976 | chr6:35498098 | TULP1 | chr6:35465653-35480647:- | -0.27 | -3.76 | 0.000195 | Hepatitis C induced liver fibrosis |
| THCA | cis | rs1577917 | 1 | rs6936048 | chr6:86702608 | SNHG5 | chr6:86386726-86388451:- | -0.48 | -10.68 | 5.19E-24 | Response to antipsychotic treatment |
| THCA | cis | rs9469890 | 1 | rs6936177 | chr6:34783717 | C6orf106 | chr6:34555066-34664625:- | 0.2 | 3.38 | 0.000796 | Pubertal anthropometrics |
| THCA | cis | rs9469890 | 1 | rs6936177 | chr6:34783717 | SNRPC | chr6:34725312-34741571:+ | -0.14 | -3.47 | 0.000558 | Pubertal anthropometrics |
| THCA | cis | rs9469890 | 1 | rs6938239 | chr6:34683635 | C6orf106 | chr6:34555066-34664625:- | -0.22 | -3.57 | 0.000393 | Pubertal anthropometrics |
| THCA | cis | rs568617 | 1 | rs693824 | chr11:65654783 | CTSW | chr11:65647284-65651212:+ | -0.6 | -15.88 | 6.69E-46 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs693824 | chr11:65654783 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 9.47 | 1.33E-19 | Crohn's disease |
| THCA | cis | rs9356009 | 1 | rs6938385 | chr6:158371962 | SNX9 | chr6:158244294-158366109:+ | -0.29 | -4.41 | 1.27E-5 | Lipoprotein (a) - cholesterol levels |
| THCA | cis | rs9400467 | 1 | rs6938986 | chr6:111436452 | KIAA1919 | chr6:111580482-111590259:+ | -0.23 | -5.06 | 6.08E-7 | Blood metabolite levels;Amino acid levels |
| THCA | cis | rs1056667 | 1 | rs6940053 | chr6:26562122 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.29 | 2.18E-5 | Educational attainment |